Trifluoroacetic acid → 3-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide

HRID 1527508노트

반응식

HRID 1527508 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15](=[O:22])[NH:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])[CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:12]=[C:11]([Cl:23])[C:10]=1[F:24])[C:15]([NH:16][CH2:17][CH2:18][N:19]([CH3:21])[CH3:20])=[O:22]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68283713[3-Chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester

생성물 1

HCID 682830433-Aminomethyl-5-chloro-N-(2-dimethylamino-ethyl)-4-fluoro-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

was prepared according to Scheme C3 (step B) from [3-chloro-5-(2-dimethylamino-ethylcarbamoyl)-2-fluoro-benzyl]-carbamic acid tert-butyl ester (120 mg, 0.3 mmol) and TFA (1 mL) in CH2Cl2. MS (LC-MS): 274.0 [M]+; tR (HPLC conditions c): 2.17 min.

후처리

  1. customwas prepared
  2. custom2.17 min.

출처 및 근거

ORD 기록
ord-2344b629bcd9444da031ef7a39d29d76
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

반응 노트

불러오는 중…