Trifluoroacetic acid → (3-Aminomethyl-5-chloro-4-fluoro-phenyl)-(4-methyl-piperazin-1-yl)-methanone

HRID 1527512노트

반응식

HRID 1527512 반응식
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[O:16])[CH:12]=[C:11]([Cl:24])[C:10]=1[F:25])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([CH3:23])[CH2:19][CH2:18]2)=[O:16])[CH:12]=[C:11]([Cl:24])[C:10]=1[F:25]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68284397[3-Chloro-2-fluoro-5-(4-methyl-piperazine-1-carbonyl)-benzyl]-carbamic acid tert-butyl ester

생성물 1

HCID 71009355(3-Aminomethyl-5-chloro-4-fluoro-phenyl)-(4-methyl-piperazin-1-yl)-methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

was prepared according to Scheme C3 (step B) from [3-chloro-2-fluoro-5-(4-methyl-piperazine-1-carbonyl)-benzyl]-carbamic acid tert-butyl ester (165 mg, 0.43 mmol) and TFA (2 mL) in CH2Cl2. MS (LC-MS): 286.0 [M]+; tR (HPLC conditions c): 1.47 min.

후처리

  1. customwas prepared
  2. custom1.47 min.

출처 및 근거

ORD 기록
ord-5dda4c816eaa4f94afc67dc791112b5a
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09085555B2

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