1,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate → 3-(2-Aminoethoxy)propanoic acid

HRID 1527651노트

반응식

HRID 1527651 반응식
C([O:5][C:6](=[O:20])[CH2:7][CH2:8][O:9][CH2:10][CH2:11][NH:12]C(OC(C)(C)C)=O)(C)(C)C>FC(F)(F)C(O)=O>[NH2:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][C:6]([OH:20])=[O:5]

참가 물질

3

반응물 1

HCID 894222391,1-Dimethylethyl 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]propanoate

생성물 1

HCID 144623893-(2-Aminoethoxy)propanoic acid

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

3-(2-tert-Butoxycarbonylamino-ethoxy)-propionic acid tert-butyl ester (10 g) was dissolved in a 1:1 trifluoroacetic acid (TFA)/DCM mixture (100 mL) and stirred at room temperature for 1 h. The solvent was then removed on a rotary evaporator and the resulting oil was re-dissolved in DCM and concentrated to dryness. This process was repeated until minimal TFA scent remained before the oil was dried on high vacuum for several hours.

후처리

  1. customThe solvent was then removed on a rotary evaporator
  2. dissolutionthe resulting oil was re-dissolved in DCM
  3. concentrationconcentrated to dryness
  4. customwas dried on high vacuum for several hours

출처 및 근거

ORD 기록
ord-79c3a0141fc3499580561f46adf7e903
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09089611B2

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