(E)-3-(1,4-Naphthoquinon-2-yl)-2-methylpropenoic acid → (E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid

HRID 1527699노트

반응식

HRID 1527699 반응식
C[O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([O:13]C)=[C:5](SC)[C:4]=1/[CH:17]=[C:18](\[CH3:22])/[C:19]([OH:21])=[O:20].C1(=O)C2C(=CC=CC=2)[C:26](=[O:33])C=C1/C=C(\C)/C(O)=O>CCOCC>[CH3:26][O:33][C:5]1[C:6](=[O:13])[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3](=[O:2])[C:4]=1/[CH:17]=[C:18](\[CH3:22])/[C:19]([OH:21])=[O:20]

참가 물질

4

반응물 2

HCID 25235423(E)-3-(1,4-Naphthoquinon-2-yl)-2-methylpropenoic acidHCID 46180316(E)-3-(1,4-dimethoxy-3-methylsulfanylnaphthalen-2-yl)-2-methylpropenoic acid

생성물 1

HCID 25235468(E)-3-(3-Methoxy-1,4-naphthoquinon-2-yl)-2-methylpropenoic Acid

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Compound 55 was prepared from 99h (0.180 g, 0.565 mmol) as described above for 30a to give 0.063 g (0.22 mmol, 38%) of the product as a red fluffy solid following flash chromatography (2:3 Et2O:hexanes 0.5% AcOH) and recrystallization from Et2O/hexanes.

후처리

  1. customto give

출처 및 근거

ORD 기록
ord-b688f82b34cb46f680d395466cb7d424
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09089605B2

반응 노트

불러오는 중…