N-{5-[2-chloro-5-(trifluoromethyl)phenyl]pyrazin-2-yl}-2,6-difluorobenzamide → N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide

HRID 1527996

반응식

HRID 1527996 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:12]1[N:13]=[CH:14][C:15]([NH:18][C:19](=[O:28])[C:20]2[C:25]([F:26])=[CH:24]C=[CH:22][C:21]=2F)=[N:16][CH:17]=1.FC1C=[N:37]C=CC=1C(Cl)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:9])[F:11])=[CH:4][C:3]=1[C:12]1[N:13]=[CH:14][C:15]([NH:18][C:19](=[O:28])[C:20]2[CH:21]=[CH:22][N:37]=[CH:24][C:25]=2[F:26])=[N:16][CH:17]=1

참가 물질

3

반응물 2

HCID 11546102N-{5-[2-chloro-5-(trifluoromethyl)phenyl]pyrazin-2-yl}-2,6-difluorobenzamideHCID 232877573-Fluoroisonicotinoyl chloride

생성물 1

HCID 11596400N-[5-(2-Chloro-5-trifluoromethyl-phenyl)-pyrazin-2-yl]-3-fluoro-isonicotinamide

실험 절차

Compound 2 was prepared in an analogous fashion to Compound 1 except that 3-fluoro-isonicotinoyl chloride was used instead of 2,6-difluoro-benzoyl chloride.

출처 및 근거

ORD 기록
ord-9aca98d6d11f43f5a116f360ffe7d729
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090570B2

연결된 노트

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