4-Chloro-3-fluorophenylboronic Acid → 5-(4-Chloro-3-fluorophenyl)-6-(2-methoxyethoxy)nicotinic acid

반응식

Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH2:10][O:11][CH3:12].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][C:18]=1[F:26]>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:13]([OH:15])=[O:14])=[CH:19][C:18]=1[F:26]

참가 물질

반응물 2

HCID 27786564-Chloro-3-fluorophenylboronic Acid

HCID 211097055-Bromo-6-(2-methoxy-ethoxy)-nicotinic acid

생성물 1

HCID 666787065-(4-Chloro-3-fluorophenyl)-6-(2-methoxyethoxy)nicotinic acid

실험 절차

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2-methoxyethoxy)-3-pyridinecarboxylic acid (CAN 912454-34-3) and B-(4-chloro-3-fluorophenyl)-boronic acid (CAN 137504-86-0) as starting materials; LC-MS (UV peak area/ESI) 100%, 324.0456 (M−H)−.

출처 및 근거

ORD 기록: ord-459c28aef93747d8bb5efc18517cff7a
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09090599B2

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