(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → (S)-5-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(1,1,1-trifluoropropan-2-yloxy)pyridazine-3-carboxamide
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:21](O)=[O:22])[N:11]=[N:12][C:13]=2[O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.Cl.[CH3:25][O:26][C:27]1[CH:31]=[C:30]([CH2:32][NH2:33])[O:29][N:28]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:21]([NH:33][CH2:32][C:30]3[O:29][N:28]=[C:27]([O:26][CH3:25])[CH:31]=3)=[O:22])[N:11]=[N:12][C:13]=2[O:14][C@@H:15]([CH3:20])[C:16]([F:17])([F:19])[F:18])=[CH:4][CH:3]=1참가 물질
3
반응물 2
생성물 1
실험 절차
The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridazine-3-carboxylic acid (example AG) and 3-methoxy-5-isoxazole-methanamine hydrochloride as starting materials, 457.1 (M+H)+.
출처 및 근거
- ORD 기록
- ord-4457cef626b24b80a62fd9df1d4b4c1d