Dimethyl Sulfone → Pyridine, 2-bromo-6-[(methylsulfonyl)methyl]-

반응식

[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[N:3]=1.[CH3:9][S:10]([CH3:13])(=[O:12])=[O:11]>>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])[N:3]=1

참가 물질

반응물 2

HCID 6213Dimethyl Sulfone

HCID 6394382-Bromo-6-fluoropyridine

생성물 1

HCID 59526086Pyridine, 2-bromo-6-[(methylsulfonyl)methyl]-수율 70%

실험 절차

The title compound was prepared from 2-bromo-6-fluoro-pyridine and dimethylsulfone following a procedure analogous to that described in Step 1 for Intermediate 14. Yield: ca. 70% of theory (crude); LC (method 3): tR=1.98 min; Mass spectrum (ESI+): m/z=250/252 (Br) [M+H]+.

출처 및 근거

ORD 기록: ord-800b6d0e7be94938b77ee33523bbb193
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09090605B2

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