Dimethylamine → 1-(6-Bromo-pyridin-2-yl)-cyclopropanecarboxylic acid dimethylamide

HRID 1528587노트

반응식

[Br:1][C:2]1[N:7]=[C:6]([C:8]2([C:11]([OH:13])=O)[CH2:10][CH2:9]2)[CH:5]=[CH:4][CH:3]=1.[CH3:14][NH:15][CH3:16]>>[CH3:14][N:15]([CH3:16])[C:11]([C:8]1([C:6]2[CH:5]=[CH:4][CH:3]=[C:2]([Br:1])[N:7]=2)[CH2:10][CH2:9]1)=[O:13]

참가 물질

반응물 2

HCID 674Dimethylamine

HCID 722119951-(6-Bromopyridin-2-YL)cyclopropane-1-carboxylic acid

생성물 1

HCID 866961361-(6-Bromo-pyridin-2-yl)-cyclopropanecarboxylic acid dimethylamide수율 70%

실험 절차

The title compound was prepared from 1-(6-bromo-pyridin-2-yl)-cyclopropanecarboxylic acid and dimethylamine (2 mol/L in tetrahydrofuran) following a procedure analogous to that described in Step 2 for Intermediate 5. Yield: 70% of theory; LC (method 3): tR=2.97 min; Mass spectrum (ESI+): m/z=255/257 (Br) [M+H]+.

출처 및 근거

ORD 기록: ord-6f654f6fa44b4240b88ec0fbbe78237b
출처 데이터셋: uspto-grants-2015_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09090605B2

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