Ethyl 4-methylidenecyclohexane-1-carboxylate → 4-Methylenecyclohexylmethanol

반응식

C([O:3][C:4]([CH:6]1[CH2:11][CH2:10][C:9](=[CH2:12])[CH2:8][CH2:7]1)=O)C.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[CH2:12]=[C:9]1[CH2:10][CH2:11][CH:6]([CH2:4][OH:3])[CH2:7][CH2:8]1

참가 물질

반응물 2

HCID 15151435Ethyl 4-methylidenecyclohexane-1-carboxylate

HCID 21226445Aluminium lithium hydride

생성물 1

HCID 138604-Methylenecyclohexylmethanol

실험 절차

The reduction reaction of 4-methylene-cyclohexanecarboxylic acid ethyl ester with LAH is as described in the above reference. The product was purified by distillation to provide (4-methylene-cyclohexyl)-methanol as clear oil (3.67 g, 29.09 mmol, 50% over Step A and B).

후처리

distillationThe product was purified by distillation

출처 및 근거

ORD 기록: ord-3c57686b1d0049178aa5b0b71d067ff8
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07732449B2

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