Sodium Iodide → HCID 66577474, 화합물

HRID 1528929노트

반응식

HRID 1528929 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]=[O:15])=[CH:4][CH:3]=1.Br[C:17]([F:21])([F:20])[CH:18]=[CH2:19].[In].[I-].[Na+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH:14]([OH:15])[C:17]([F:21])([F:20])[CH:18]=[CH2:19])=[CH:6][CH:7]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 5550853-bromo-3,3-difluoroprop-1-eneHCID 5359967IndiumHCID 821337925-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde

생성물 1

HCID 66577474HCID 66577474, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carbaldehyde (0.511 g, 1.92 mmol), 3-bromo-3,3-difluoro-propene (0.4977 g, 3.07 mmol), indium (0.357 g, 3.07 mmol) and sodium iodide (0.0142 g, 0.096 mmol) were combined in DMF (5 mL) and stirred at room temperature overnight. The reaction mixture was submitted to standard aqueous workup to afford the title compound, which was taken to the next step without further purification.

출처 및 근거

ORD 기록
ord-f950925210184f89b087c5e434da46eb
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090573B2

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