Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Indoline → Adamantan-2-yl-(2,3-dihydro-indol-1-yl)-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Indoline | HCID 10328 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Adamantanecarboxylic acid | HCID 303802 | — |
| 반응물 | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| 용매 | Formic Acid | HCID 284 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Adamantan-2-yl-(2,3-dihydro-indol-1-yl)-methanone | HCID 71559641 | — |
반응 단계
A mixture of 24.2 mg (0.134 mmol) adamantane-2-carboxylic acid, 20 mg (0.168 mmol) indoline, 64.7 mg (0.2 mmol) TBTU and 43.4 mg (0.336 mmol) DIPEA in 1 mL DMF was stirred at room temperature overnight. Formic acid was added and the mixture was subjected to column chromatography on reversed phase eluting with a gradient formed from acetonitrile, water and NEt3 to yield after evaporation of the product containing fractions 14.1 mg (30%) of the title compound. MS(m/e): 282.4 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09090615B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-5084855ac78d47e5b4607fbee6b47503 |
| 출처 메모 | uspto-grants-2015_07 |