Potassium Carbonate → Methyl thieno[3,2-c]pyridine-2-carboxylate

HRID 1529481노트

반응식

HRID 1529481 반응식
Br[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[CH:8]=O.C([O-])([O-])=O.[K+].[K+].[C:16]([O:20][CH3:21])(=[O:19])[CH2:17][SH:18]>CN(C=O)C.O>[CH3:21][O:20][C:16]([C:17]1[S:18][C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[CH:8]=1)=[O:19]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 16907Methyl ThioglycolateHCID 111167404-Bromopyridine-3-carbaldehyde

생성물 1

HCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
45 °C

실험 절차

To a solution of 4-bromo-pyridine-3-carbaldehyde (1.50 g, 8.06 mmol) in DMF (10 mL) and water (1 mL) was added K2CO3 (1.34 g, 9.68 mmol) and methyl thioglycolate (0.87 mL, 9.68 mmol). The mixture was heated at 45° C. for 18 hours. The reaction mixture was removed from the heating bath and diluted with water (50 mL). After 1 hour, the fluffy solid that formed was filtered and washed with water. The material thus obtained was dried in a 60° C. vacuum oven to a constant weight of 0.92 g (59%). MS m/z 194 (M+H)+.

후처리

  1. customThe reaction mixture was removed from the heating bath
  2. additiondiluted with water (50 mL)
  3. customthe fluffy solid that formed
  4. filtrationwas filtered
  5. washwashed with water
  6. customThe material thus obtained
  7. customwas dried in a 60° C. vacuum oven to a constant weight of 0.92 g (59%)

출처 및 근거

ORD 기록
ord-bebb88c4748d48f6a83f58658fc93112
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090625B2

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