Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Stannous Chloride → N-(3-amino-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)-4-chlorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 4-chloro-N-(4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3-nitrophenyl)benzamide | HCID 67467095 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N-(3-amino-4-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)phenyl)-4-chlorobenzamide | HCID 67464229 | — |
반응 단계
Compound 16 (42 mg, 0.1 mmol) was dissolved in 10 ml MeOH. Tin(II)chloride dehydrate (223 mg, 1 mmol) was added and the reaction mixture was stirred at r.t. for overnight. The reaction mixture was evaporated to dryness. The solid residue was dissolved in 6 N NaOH and extracted with DCM. The org. phase was washed with brine. After concentrated to dryness, the solid residue was dissolved in DMF and purified on prep HPLC to give compound 17.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09090612B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-f7e25a5fe4e647148fcd7e68fe4c4410 |
| 출처 메모 | uspto-grants-2015_07 |