Tetrafluoro-m-phenylenediamine dihydrochloride → Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride

참여 물질

역할	이름	HCID	투입량
반응물	Tetrafluoro-m-phenylenediamine dihydrochloride	HCID 149026	—
반응물	Ether hydrochloride	HCID 10953452	—
반응물	Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one	HCID 24871549	—
용매	Chloroform	HCID 6212	—
생성물	Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one dihydrochloride	HCID 68685184	—

반응 단계

Racemic 3-chloro-4-[(4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]thiazin-6-yl)methyl]amino}-1-piperidinyl)methyl]-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one was converted to the dihydrochloride by dissolving in chloroform and adding 1M HCl/diethyl ether then evaporating to dryness. MS as that of free base.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07732461B2
출처 데이터셋	uspto-grants-2010_06
ORD ID	ord-5c06d8d3ee3c47bbbd4173856818d6b2
출처 메모	uspto-grants-2010_06