Potassium tert-butoxide → HCID 68312970, 화합물
반응식
CC(C)([O-])C.[K+].[CH3:7][O:8][C:9](=[O:38])[CH:10]([O:14][C:15]1[CH:37]=[CH:36][C:18]2[C:19]3[N:23]([CH2:24][CH2:25][O:26][C:17]=2[CH:16]=1)[CH:22]=[C:21]([C:27]1[N:28]([CH:33]([CH3:35])[CH3:34])[N:29]=[C:30]([CH3:32])[N:31]=1)[N:20]=3)[CH2:11][CH2:12]Br>C1COCC1.O>[CH3:7][O:8][C:9]([C:10]1([O:14][C:15]2[CH:37]=[CH:36][C:18]3[C:19]4[N:23]([CH2:24][CH2:25][O:26][C:17]=3[CH:16]=2)[CH:22]=[C:21]([C:27]2[N:28]([CH:33]([CH3:35])[CH3:34])[N:29]=[C:30]([CH3:32])[N:31]=2)[N:20]=4)[CH2:12][CH2:11]1)=[O:38]참가 물질
5
실험 절차
Potassium tertbutoxide (611 mg, 5.45 mmol) was added to a solution of 4-bromo-2-[2-(2-isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]butyric acid methyl ester (2.5 g, 4.96 mmol) in THF (20 mL) and the mixture was stirred at RT for 30 min. The crude reaction mixture was diluted with water and extracted with EtOAc (×3). The combined organic layers were washed with brine, then dried and concentrated in vacuo. The resulting residue was purified by column chromatography (Si-PCC, gradient 0-7% MeOH in DCM) affording 1-[2-(2-Isopropyl-5-methyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-1,3a-diazabenzo[e]azulen-8-yloxy]cyclopropanecarboxylic acid methyl ester (1.4 g, 67%). 1H NMR (CDCl3, 400 MHz): δ 8.42 (1H, d, J=8.98 Hz), 7.56 (1H, s), 6.75 (1H, dd, J=8.97, 2.58 Hz), 6.58 (1H, d, J=2.55 Hz), 5.97-5.82 (1H, m), 4.50-4.35 (4H, m), 3.74 (3H, s), 2.40 (3H, s), 1.67-1.60 (2H, m), 1.55 (6H, d, J=6.52 Hz), 1.38-1.31 (2H, m)