Ammonia → 4-Bromo-2-fluorobenzimidamide hydrochloride

HRID 1530481노트

반응식

HRID 1530481 반응식
[ClH:1].C(O[C:5](=[NH:14])[C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][C:7]=1[F:13])C.[NH3:15]>>[ClH:1].[Br:12][C:9]1[CH:10]=[CH:11][C:6]([C:5]([NH2:14])=[NH:15])=[C:7]([F:13])[CH:8]=1

참가 물질

3

반응물 2

HCID 222AmmoniaHCID 670507354-Bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride

생성물 1

HCID 534078914-Bromo-2-fluorobenzimidamide hydrochloride수율 100%

실험 절차

A mixture of 4-bromo-2-fluoro-benzimidic acid ethyl ester hydrochloride (20.3 g, 72 mmol) in IMS (250 mL) at 0-5° C. was saturated with NH3 (gas), and the flask sealed before allowing to warm to RT and stirring for 18 h. Solvent was removed in vacuo and the residue triturated in diethyl ether to give 4-Bromo-2-fluoro-benzamidine hydrochloride as a white solid (18.1 g, 100%). 1H NMR δ (ppm) (DMSO-d6): 9.26 (4H, s), 7.92-7.87 (1H, m), 7.71-7.62 (2H, m).

후처리

  1. customthe flask sealed
  2. customSolvent was removed in vacuo
  3. customthe residue triturated in diethyl ether

출처 및 근거

ORD 기록
ord-885234a4e94d43f58288a762ffb98d1d
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09090628B2

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