Diethyl 2-(4-(benzyloxy)phenyl)malonate → Dimethyl (4-hydroxyphenyl)malonate

HRID 1530809

반응식

HRID 1530809 반응식
[H][H].C([O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:23]([O:25][CH2:26]C)=[O:24])[C:18]([O:20][CH2:21]C)=[O:19])=[CH:13][CH:12]=1)C1C=CC=CC=1>CO.[Pd]>[OH:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]([C:23]([O:25][CH3:26])=[O:24])[C:18]([O:20][CH3:21])=[O:19])=[CH:13][CH:12]=1

참가 물질

5

반응물 2

HCID 2823246Diethyl 2-(4-(benzyloxy)phenyl)malonateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 3018973Dimethyl (4-hydroxyphenyl)malonate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

At room temperature and a hydrogen pressure of 5 bar, 94.3 g of diethyl (4-benzyloxyphenyl)malonate (J. Org. Chem. 46, 3007 (1981)) in 500 ml of methanol were hydrogenated in the presence of 5 g of palladium/carbon catalyst (5%). The catalyst was filtered off and the mixture was concentrated, to give the title product as a colourless oil.

후처리

  1. customAt room temperature
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

출처 및 근거

ORD 기록
ord-77406f95a9a6483b881a31d1e265654e
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197729B1

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