Dimethyl (4-hydroxyphenyl)malonate → Dimethyl (4-hydroxycyclohexyl)malonate

HRID 1530810노트

반응식

HRID 1530810 반응식
[H][H].[OH:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:15]([O:17][CH3:18])=[O:16])[C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:5]=1>CO.[Rh]>[OH:3][CH:4]1[CH2:5][CH2:6][CH:7]([CH:10]([C:11]([O:13][CH3:14])=[O:12])[C:15]([O:17][CH3:18])=[O:16])[CH2:8][CH2:9]1

참가 물질

5

반응물 2

HCID 3018973Dimethyl (4-hydroxyphenyl)malonateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 91368111Dimethyl (4-hydroxycyclohexyl)malonate

시약·촉매·용매 2

HCID 23948Rhodium촉매HCID 887Methanol용매

실험 절차

At 60° C. and a hydrogen pressure of 150 bar, 67.3 g of dimethyl (4-hydroxyphenyl)malonate in 500 ml of methanol were hydrogenated in the presence of 5 g of rhodium/carbon catalyst (5%). The catalyst was filtered off and the mixture was concentrated. This to give the title product as a colourless oil.

후처리

  1. customAt 60° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

출처 및 근거

ORD 기록
ord-680e2cf6c9d64e7d9dcd6c264458d4fe
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197729B1

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