HCID 178418361, 화합물 → HCID 178511562, 화합물

HRID 1530820노트

반응식

HRID 1530820 반응식
[H][H].C([NH:10][C@H:11]1[CH2:16][CH2:15][C@@H:14]([CH:17]([OH:22])[C:18]([F:21])([F:20])[F:19])[CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[OH:22][CH:17]([C@@H:14]1[CH2:15][CH2:16][C@H:11]([NH2:10])[CH2:12][CH2:13]1)[C:18]([F:19])([F:20])[F:21]

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178520974HCID 178520974, 화합물

생성물 1

HCID 178511562HCID 178511562, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

At 50° C. and a hydrogen pressure of 30 bar, 33.6 g of cis-1-benzylamino-4-(1-hydroxy-2,2,2-trifluoroethyl)cyclohexane were hydrogenated in the presence of 2 g of palladium (10% on carbon) in 250 ml of methanol. The catalyst was filtered off and the mixture was concentrated to give the title product as a colourless oil.

후처리

  1. customAt 50° C.
  2. filtrationThe catalyst was filtered off
  3. concentrationthe mixture was concentrated

출처 및 근거

ORD 기록
ord-724ea9b0a7d94277b3c8bdb0f6195cd7
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197729B1

반응 노트

불러오는 중…