Triethylamine → 4-(4-Iodophenyl)morpholine
반응식
[I:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Br[CH2:10][CH2:11][O:12][CH2:13][CH2:14]Br.CCN(CC)CC>CN(C=O)C.CCOC(C)=O>[I:1][C:2]1[CH:8]=[CH:7][C:5]([N:6]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1참가 물질
6
반응 조건
- 온도
- 60 °C
실험 절차
Methyl 2-N-boc-amino-5-(4-morpholinophenyl)-pent-4-ynoate: 4-Iodoaniline (6.2 g, 28.4 mmol) is taken in 50 mL of DMF in the presence of 8 mL of bromoethyl ether and 10 mL of Et3N and heated to 60° C. for 24 hr. The mixture is then diluted with EtOAc, and washed 3x with dil. NaHCO3, 1x with brine, dried over MgSO4, filtered and evaporated. The residue is then recrystallized from MeOH to give 4.21 g of 4-iodophenylmorpholine as a pale brown solid.
후처리
- washwashed 3x with dil. NaHCO3, 1x with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customThe residue is then recrystallized from MeOH
출처 및 근거
- ORD 기록
- ord-55cfd07e5a8f49d8af6616f4918f00b1
- 출처 데이터셋
- uspto-grants-2001_03
- 특허 번호
- US06197770B1
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