HCID 70223394, 화합물 → HCID 70226124, 화합물

HRID 1531555노트

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HRID 1531555 반응식
[C:1]([O:5][C:6](=[O:49])[N:7]([CH2:27][CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([N+:38]([O-])=O)[CH:36]=2)[NH:31][C:30]=1[C:41]1[CH:46]=[C:45]([CH3:47])[CH:44]=[C:43]([CH3:48])[CH:42]=1)[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([S:19]([CH3:22])(=[O:21])=[O:20])[C:13]=1[S:23]([CH3:26])(=[O:25])=[O:24])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:49])[N:7]([CH2:27][CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([NH2:38])[CH:36]=2)[NH:31][C:30]=1[C:41]1[CH:42]=[C:43]([CH3:48])[CH:44]=[C:45]([CH3:47])[CH:46]=1)[CH2:8][CH2:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([NH2:18])=[C:14]([S:19]([CH3:22])(=[O:20])=[O:21])[C:13]=1[S:23]([CH3:26])(=[O:25])=[O:24])([CH3:2])([CH3:4])[CH3:3]

참가 물질

3

반응물 1

HCID 70223394HCID 70223394, 화합물

생성물 1

HCID 70226124HCID 70226124, 화합물수율 90.5%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

The title compound was prepared essentially as described in EXAMPLE 2.1 StepE starting from {2-[2-(3,5-dimethylphenyl)-5-nitro-1H-indol-3-yl]-ethyl}-[4-(4-amino(dimethanesulfonyl)phenyl)butyl]-carbamic acid tert-butyl ester (330 mg) and using 10% palladium on carbon as catalyst to give the title compound (286 mg).

후처리

  1. customThe title compound was prepared essentially

출처 및 근거

ORD 기록
ord-9c0ead58e03b448fadee5f49f3d750af
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06197975B1

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