Ethyl bromoacetate → 2-[3-Hydroxy-5-[hydroxymethyl]phenyloxy]acetic acid, ethyl ester

반응식

[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([OH:10])[CH:9]=1)[CH2:5][OH:6].Br[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[OH:1][C:2]1[CH:9]=[C:8]([O:10][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH:7]=[C:4]([CH2:5][OH:6])[CH:3]=1

참가 물질

반응물 2

HCID 7748Ethyl bromoacetate

HCID 346613,5-Dihydroxybenzyl alcohol

생성물 1

HCID 1210064842-[3-Hydroxy-5-[hydroxymethyl]phenyloxy]acetic acid, ethyl ester

실험 절차

the subtitle compound was prepared from 3,5-dihydroxybenzyl alcohol (5 g) and ethyl bromoacetate (5.96 g) by the method of example 21 step (ii). Purified by chromatography eluting with 30% ethyl acetate in isohexane. Yield 1.6 g.

후처리

customPurified by chromatography
washeluting with 30% ethyl acetate in isohexane

출처 및 근거

ORD 기록: ord-73387faa66d54a03a2d15275ebeac7c2
출처 데이터셋: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06200981B1

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