Methylamine → 2-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one

HRID 1532091노트

반응식

[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[N:19]=[C:18]2[C:14](=[N:15][CH:16]=[N:17]2)[C:13](=[O:20])[N:12]=1)[CH2:2][CH3:3].Cl[S:22]([OH:25])(=O)=[O:23].[CH3:26][NH2:27]>>[CH2:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([S:22](=[O:25])(=[O:23])[NH:27][CH3:26])=[CH:7][C:6]=1[C:11]1[N:19]=[C:18]2[C:14](=[N:15][CH:16]=[N:17]2)[C:13](=[O:20])[N:12]=1)[CH2:2][CH3:3]

참가 물질

반응물 3

HCID 6329Methylamine

HCID 24638Chlorosulfonic acid

HCID 18409955HCID 18409955, 화합물

생성물 1

HCID 212507872-(2-Propoxy-5-methylsulphamoylphenyl)purin-6-one

실험 절차

In a similar manner to Example 49 reaction of 2-(2-propoxyphenyl)purin-6-one (0.81 g) with chlorosulphonic acid (4.5 ml), followed by reaction with methylamine in industrial methylated spirit (33%, 50 ml) yielded the title compound, 0.49 g, m.p. 245-246° C. (recrystallised twice from aqueous ethanol).

출처 및 근거

ORD 기록: ord-f4a5838f8f464563a0344c9d51b2e8e7
출처 데이터셋: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06200980B1

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