2-Propyl-4-pyrazinyloxyphenol → Ethyl 4-(3-(2-propyl-4-pyrazinyloxyphenoxy)-propoxy)mandelate

반응식

[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)[CH:7]=[CH:6][C:5]=1[OH:17])[CH2:2][CH3:3].Br[CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:35]=[CH:34][C:26]([CH:27]([OH:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:25][CH:24]=1>>[CH2:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[CH:16]=[N:15][CH:14]=[CH:13][N:12]=2)[CH:7]=[CH:6][C:5]=1[O:17][CH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:35]=[CH:34][C:26]([CH:27]([OH:33])[C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:25][CH:24]=1)[CH2:2][CH3:3]

참가 물질

반응물 2

HCID 224589672-Propyl-4-pyrazinyloxyphenol

HCID 22459007Ethyl 4-(3-bromopropoxy)mandelate

생성물 1

HCID 22458969Ethyl 4-(3-(2-propyl-4-pyrazinyloxyphenoxy)-propoxy)mandelate

실험 절차

The title compound was prepared according to the method described in Example 22, Step C using 2-propyl-4-pyrazinyloxyphenol (19.0 g, 62.0 mmol) and ethyl 4-(3-bromopropoxy)mandelate (19.5 g, 58.9 mnol) (as prepared in Example 22, Step C) as the starting materials.

출처 및 근거

ORD 기록: ord-ba3ffe6eab184bfab8db8b0e209b9024
출처 데이터셋: uspto-grants-2001_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06200998B1

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