Water → (R)-1-Benzyl-3-pyrrolidinol tosylate

HRID 1532254

반응식

HRID 1532254 반응식
[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[CH:16][CH:15]=1.[OH2:25]>N1C=CC=CC=1>[CH2:1]([N:8]1[CH2:12][CH2:11][C@@H:10]([OH:13])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[S:20]([C:17]1[CH:18]=[CH:19][C:14]([CH3:24])=[CH:15][CH:16]=1)([O-:22])(=[O:21])=[O:25]

참가 물질

5

반응물 3

HCID 962WaterHCID 73974-Toluenesulfonyl chlorideHCID 643472(R)-(+)-1-Benzyl-3-pyrrolidinol

생성물 1

HCID 86583595(R)-1-Benzyl-3-pyrrolidinol tosylate수율 92%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a stirred solution of (R)-1-benzyl-3-pyrrolidinol (1.77 g, 10 mmol) in pyridine(30 ml) was added p-toluenesulfonyl chloride (9.53 g, 50 mmol) by portions at 0° C. After 90 h stirring at room temperature, water was added to the reaction mixture and the mixture was extracted with ether (150 ml). The extract was washed with water, brine, dried(Na2SO4), and concentrated to give 3.06 g (92%) of brown oil.

후처리

  1. extractionthe mixture was extracted with ether (150 ml)
  2. washThe extract was washed with water, brine, dried(Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b0d79f5e360b4e2bbdeea790d4f23034
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06201007B1

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