4-Chloro-3-[(carboxymethyl)sulfonyl]benzoic acid methyl ester → Methyl 4-chloro-3-(methylsulfonyl)benzoate
반응식
[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([S:11]([CH2:14]C(O)=O)(=[O:13])=[O:12])[CH:5]=1>N1C=CC=CC=1>[CH3:1][O:2][C:3](=[O:18])[C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:5]=1참가 물질
3
실험 절차
4-Chloro-3-[(carboxymethyl)sulfonyl]benzoic acid methyl ester (5.6 g) was mixed with pyridine (10 mL) and the mixture was refluxed for 30 min and then cooled to room temperature. The product was precipitated by adding water (30 mL). The precipitate was filtered, washed with water and dried (yield 2.5 g). 1H-NMR (400 MHz, DMSO-d6) d=3.43 (s, 3H), 3.92 (s, 3H), 7.92 (d, J=8.2 Hz, 1H), 8.24 (dd, J=8.2 Hz, 2.2 Hz, 1H), 8.53 (d, J=2.2 Hz, 1H).
후처리
- temperaturethe mixture was refluxed for 30 min
- customThe product was precipitated
- additionby adding water (30 mL)
- filtrationThe precipitate was filtered
- washwashed with water
- customdried (yield 2.5 g)
출처 및 근거
- ORD 기록
- ord-2620efac3d594871b2efc815fec98769
- 출처 데이터셋
- uspto-grants-2001_03
- 특허 번호
- US06201027B1
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