Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylsilyl triflate → 3,4-Dichloro-2-(isopropylamino)-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylsilyl triflate | HCID 65367 | — |
| 반응물 | (2R,3S,4S,5S)-5-(acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate | HCID 908100 | — |
| 반응물 | N,O-bis(trimethylsilyl)acetamide | HCID 6913588 | — |
| 반응물 | 3,4-Dichloro-2-(isopropylamino)-1H-benzimidazole | HCID 22995452 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 3,4-Dichloro-2-(isopropylamino)-1-(2,3,5-tri-O-acetyl-beta-L-ribofuranosyl)-1H-benzimidazole | HCID 57222824 | 56.4% |
반응 단계
3,4-Dichloro-2-(isopropylamino)-1H-benzimidazole (2.01 g, 7.31 mmol), N,O-bis(trimethylsilyl)acetamide (2.0 mL, 1.65 g, 8.09 mmol), trimethylsilyl trifluoromethanesulfonate (0.9 mL, 1.06 g, 4.50 mmol), 1,2,3,5-tetra-O-acetyl-beta-L-ribofuranose (3.03 g, 9.52 mmol) and 1,2-dichloroethane (35 mL) were used according to general procedure II. The product was purified by silica gel chromatography using 95:5 dichloromethane/acetonitrile to afford 2.08 g (56%) of a yellow foam. MS (EI): m/z 502.0 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06204249B1 |
| 출처 데이터셋 | uspto-grants-2001_03 |
| ORD ID | ord-47c9aae3f01b4bacb0f586b21ab22539 |
| 출처 메모 | uspto-grants-2001_03 |