Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(-)-Asparagine → N-Phenysulfonyl-L-asparagine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (-)-Asparagine | HCID 6267 | — |
| 반응물 | Benzenesulfonyl chloride | HCID 7369 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-Phenysulfonyl-L-asparagine | HCID 10754635 | — |
반응 단계
To L-Asparagine (10 g), add sodium hydroxide (3.4 g) and dioxane/water (50 mL/50 mL). Cool resulting solution in an ice bath and add benzenesulfonyl chloride (10.6 mL), sodium hydroxide (3.4 g), and water (80 mL). Stir for 3 hours. Add water (200 mL) and extract with EtOAc. Acidify the aqueous solution to pH 3 with concentrated HCl and cool to give a precipitate. After 1 hour collect the solid and dry it in vacuo at 40° C. to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06204282B1 |
| 출처 데이터셋 | uspto-grants-2001_03 |
| ORD ID | ord-afbdb89e85ab49899ea1c627af485223 |
| 출처 메모 | uspto-grants-2001_03 |