Toluene → HCID 3635836, 화합물

HRID 1532651노트

반응식

HRID 1532651 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1.Cl[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[N+:18]([O-:20])=[O:19].C1(C)C=CC=CC=1>N1C=CC=CC=1>[O:8]1[CH2:9][CH2:10][N:5]([CH2:4][CH2:3][CH2:2][NH:1][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N+:18]([O-:20])=[O:19])[CH2:6][CH2:7]1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 69451-Chloro-2-nitrobenzeneHCID 61055N-(3-Aminopropyl)morpholine

생성물 1

HCID 3635836HCID 3635836, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
130 °C

실험 절차

N-(3-Aminopropyl)morpholine (1.04 ml) was added to a solution containing 2-chloronitrobenzene (1.005 g) in pyridine (0.78 ml), and stirred for 14 hours at 130° C. Toluene was added to the reaction mixture and concentrated. The residue, with ethyl acetate added thereto, was extracted with 1N hydrochloric acid aqueous solution. The extract was alkalified with 1N sodium hydroxide aqueous solution and extracted with ethyl acetate. The extract was washed with saturated brine, dried over sodium sulfate anhydride, and concentrated, thereby yielding the entitled compound (1.217 g) as orange oil.

후처리

  1. concentrationconcentrated
  2. additionThe residue, with ethyl acetate added
  3. extractionwas extracted with 1N hydrochloric acid aqueous solution
  4. extractionextracted with ethyl acetate
  5. washThe extract was washed with saturated brine
  6. dry with materialdried over sodium sulfate anhydride
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-f1b70ab4fa164e28be5f6a784ebfd0fa
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06204264B1

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