Hydrogen chloride-ethyl acetate → HCID 22013777, 화합물

HRID 1532692노트

반응식

HRID 1532692 반응식
[ClH:1].C(OCC)(=O)C.[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]>C(OCC)(=O)C.C(O)C>[ClH:1].[CH3:8][N:9]([CH3:42])[CH2:10][CH2:11][N:12]1[C:16]2[CH:17]=[CH:18][C:19]([C:21]([NH:23][CH3:24])=[O:22])=[CH:20][C:15]=2[N:14]=[C:13]1[CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH3:41]

참가 물질

5

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 22013765HCID 22013765, 화합물

생성물 1

HCID 22013777HCID 22013777, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8857Ethyl Acetate용매

실험 절차

4N Hydrochloric acid/ethyl acetate solution (1.24 ml) was added to a solution containing 1-[2-(dimethylamino)ethyl]-2-heptadecyl-N-methyl-1H-benzimidazole-5-carboxamide (2.207 g) in a mixture of ethyl acetate (22 ml) and ethanol (2 ml). After being stirred for 30 minutes while being cooled with ice, the reaction mixture was concentrated. The residue was recrystallized with the mixed solution of ethyl acetate-ethanol, thereby yielding the entitled compound (1.751 g) as white crystals.

후처리

  1. temperaturewhile being cooled with ice
  2. concentrationthe reaction mixture was concentrated
  3. customThe residue was recrystallized with the mixed solution of ethyl acetate-ethanol

출처 및 근거

ORD 기록
ord-fe0ea16a2d7a42b3ba1d89e5c62176fb
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06204264B1

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