Benzyl bromoacetate → HCID 57313411, 화합물

HRID 1532906노트

반응식

HRID 1532906 반응식
[CH3:1][O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[C:6]1=[O:24].BrCC(OC[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=O>>[CH2:1]([O:2][C:3](=[O:25])[CH2:4][N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][CH2:8][C@H:7]([NH:16][C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])[C:6]1=[O:24])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

3

반응물 2

HCID 62576Benzyl bromoacetateHCID 54305289(3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester

생성물 1

HCID 57313411HCID 57313411, 화합물

실험 절차

Prepared by a similar method described for the preparation of 600a/103 (Step D), except benzyl bromoacetate was used instead of methyl bromoacetate to give 600b in quantitative yield.

후처리

  1. customPrepared by a similar method

출처 및 근거

ORD 기록
ord-46ed8f244ead4fb8b00f754962fb6e8d
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06204261B1

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