2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol → 2,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde

HRID 15332노트

반응식

HRID 15332 반응식
[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH2:10][OH:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1>ClCCl.[O-2].[O-2].[Mn+4]>[O:1]1[C:5]2=[CH:6][N:7]=[C:8]([CH:10]=[O:11])[CH:9]=[C:4]2[CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 574231212,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol

생성물 1

HCID 574231162,3-Dihydrofuro[2,3-c]pyridine-5-carbaldehyde수율 70%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

2,3-Dihydrofuro[2,3-c]pyridin-5-ylmethanol (1.31 g, 8.7 mmol) was dissolved in dichloromethane (100 ml) and treated with manganese dioxide (6 g, 69 mmol) at ambient temperature with vigorous stirring for 18 h. The mixture was filtered through kieselguhr and the filtrate evaporated to dryness to provide the desired compound (0.9 g, 70%).

후처리

  1. filtrationThe mixture was filtered through kieselguhr
  2. customthe filtrate evaporated to dryness

출처 및 근거

ORD 기록
ord-6c66c9facbec48ee8f5ce4b4d05f60cc
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07732461B2

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