반응식
[NH2:1][C@H:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH:9]2[C:13]3=[C:14]([F:22])[CH:15]=[N:16][C:17]4[CH:18]=[CH:19][C:20](=[O:21])[N:11]([C:12]=43)[CH2:10]2)[CH2:4][C@H:3]1[F:23].[O:24]1[C:33]2[CH:32]=[C:31]([CH:34]=O)[N:30]=[CH:29][C:28]=2[O:27][CH2:26][CH2:25]1.[Cl:36]CCl.CO>>[ClH:36].[O:24]1[C:33]2[CH:32]=[C:31]([CH2:34][NH:1][C@H:2]3[CH2:7][CH2:6][N:5]([CH2:8][CH:9]4[C:13]5=[C:14]([F:22])[CH:15]=[N:16][C:17]6[CH:18]=[CH:19][C:20](=[O:21])[N:11]([C:12]=65)[CH2:10]4)[CH2:4][C@H:3]3[F:23])[N:30]=[CH:29][C:28]=2[O:27][CH2:26][CH2:25]1참가 물질
4
반응물 3
생성물 1
실험 절차
The free base of the title compound was prepared from 4-{[cis-4-amino-3-fluoro-1-piperidinyl]methyl}3-fluoro-4,5-dihydro-7H-pyrrolo[3,2,1-de]-1,5-naphthyridin-7-one and 2,3-dihydro[1,4]dioxino[2,3-c]pyridine-7-carboxaldehyde (for a synthesis see WO2004058144, Example 2(c)) according to the general method of Example 2(h), chromatographing with dichloromethane/methanol/0.88 ammonia 95:5:0.5, in 82% yield.
출처 및 근거
- ORD 기록
- ord-abecd2ee907843208d511a526fc821ee
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07732461B2
연결된 노트
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