N,N-Dimethylethylenediamine → 2-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

HRID 1533780노트

반응식

HRID 1533780 반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH2:18].C(=O)(O)[O-].[Na+]>>[CH3:14][N:15]([CH3:19])[CH2:16][CH2:17][NH:18][C:2]1[NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1

참가 물질

4

반응물 3

HCID 66053N,N-DimethylethylenediamineHCID 516892Sodium BicarbonateHCID 14765451HCID 14765451, 화합물

생성물 1

HCID 183786772-[2-(dimethylamino)ethylamino]-4-nitro-1H-benzimidazole

반응 조건

온도
80 °C

실험 절차

A mixture of 2-chloro-4-nitro-1H-benzimidazole (300 mg) and N,N-dimethylethylenediamine (2 ml) were stirred at 80° C. for 8 hours. The reaction mixture was poured into saturated sodium bicarbonate aqueous solution and extracted with a mixture of chloroform and methanol. The organic layer was washed with brine, dried over magnesium sulfate and evaporated in vacuo. The residue was washed with diisopropyl ether to give 2-[[2-(dimethylamino)ethyl]amino]-4-nitro-1H-benzimidazole (113 mg).

후처리

  1. extractionextracted with a mixture of chloroform and methanol
  2. washThe organic layer was washed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. washThe residue was washed with diisopropyl ether

출처 및 근거

ORD 기록
ord-e6179ebf95bd4aa2a97232e4d303c645
출처 데이터셋
uspto-grants-2001_03
특허 번호
US06207693B1

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