Sodium Carbonate → HCID 53952014, 화합물

HRID 1533993노트

반응식

HRID 1533993 반응식
[CH3:1][C:2]([NH:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[CH:20]=[CH:21][NH:22]2)=[O:17])([CH3:4])[CH3:3].[Cl:27]N1C(=O)CCC1=O.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[CH3:4][C:2]([NH:5][CH2:6][CH2:7][CH2:8][O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]([C:18]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:19]=1[C:20]([Cl:27])=[CH:21][NH:22]2)=[O:17])([CH3:1])[CH3:3]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 31398ChlorosuccinimideHCID 3077190HCID 3077190, 화합물

생성물 1

HCID 53952014HCID 53952014, 화합물수율 79.8%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

6.3 g of [2-[3-[(1,1-dimethylethyl)-amino]-propoxy]-phenyl]-(1H-indol-4-yl) methanone of Step F of Example 3 in 50 ml of acetic acid in the presence of 2.64 g of N-chloro succinimide was stirred for 2 hours at ambient temperature and was then poured into 300 ml of saturated aqueous solution of sodium carbonate and extracted with ethyl acetate. The organic phase was washed with salt water, dried and concentrated to dryness. After chromatography of the residue on silica (eluant:ethyl acetate triethylamine 95-5), 5.52 g of the expected product were obtained and was used as is for the following step.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic phase was washed with salt water
  3. customdried
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-7aea540fc66f40bcbe03944dcba89d2b
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05086070

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