Dropropizine → Levodropropizine

HRID 1534140

반응식

HRID 1534140 반응식
[CH:1]1[CH:2]=[CH:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH:14]([OH:17])[CH2:15][OH:16])[CH2:9][CH2:8]2)=[CH:5][CH:6]=1.C(O)(=O)[C@@H]([C@H](C(O)=O)O)O>>[CH:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:8][CH2:9][N:10]([CH2:13][C@H:14]([OH:17])[CH2:15][OH:16])[CH2:11][CH2:12]2)=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 3169DropropizineHCID 444305L-Tartaric acid

생성물 1

HCID 65859Levodropropizine

실험 절차

According to the invention, resolution of dropropizine is carried out by treating it with L(+)tartaric acid in aqueous medium: the precipitated salt is then crystallized, alkalinized and recrystallized to give levodropropizine.

후처리

  1. customthe precipitated salt is then crystallized
  2. customrecrystallized

출처 및 근거

ORD 기록
ord-7838876847e44a8183215a35cd061918
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05087698

연결된 노트

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