3-Pyrrolidinecarboxamide, 2,2,5,5-tetramethyl- → 2,2,5,5-Tetramethylpyrrolidine-3-carboxylic acid

HRID 1534176노트

반응식

HRID 1534176 반응식
[CH3:1][C:2]1([CH3:12])[CH:6]([C:7](N)=[O:8])[CH2:5][C:4]([CH3:11])([CH3:10])[NH:3]1.[OH-:13].[Ba+2].[OH-]>>[CH3:1][C:2]1([CH3:12])[CH:6]([C:7]([OH:13])=[O:8])[CH2:5][C:4]([CH3:11])([CH3:10])[NH:3]1

참가 물질

3

반응물 2

HCID 697083-Pyrrolidinecarboxamide, 2,2,5,5-tetramethyl-HCID 6093286Barium hydroxide

생성물 1

HCID 126109972,2,5,5-Tetramethylpyrrolidine-3-carboxylic acid

실험 절차

2,2,5,5-tetramethyl pyrroline-3-carboxylic acid was prepared by the hydrolysis of 2,2,5,5-tetramethyl pyrroline-3-carboxamide (Frinton; recrystallized from benzene) with barium hydroxide. The acid was recrystallized from water to provide an off-white solid. The measured mp was 300 (dec.) in a sealed tube; the reported mp was 300 dec. (Pauly 1902; Rozantsev 1970).

후처리

  1. customThe acid was recrystallized from water
  2. customto provide an off-white solid

출처 및 근거

ORD 기록
ord-b0627d24c6a94da9be8b4645e18a4f2c
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05087752

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