Acetamide, N-(2-methyl-4-nitrophenyl)- → 2-Methyl-6-nitroaniline

HRID 1534192

반응식

HRID 1534192 반응식
C([NH:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:14])(=O)C.C(NC1C=CC([N+]([O-])=O)=CC=1C)(=O)C>>[NH2:4][C:5]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:14]

참가 물질

3

반응물 2

HCID 75936Acetamide, N-(2-methyl-4-nitrophenyl)-HCID 316249N-(2-methyl-6-nitrophenyl)acetamide

생성물 1

HCID 112982-Methyl-6-nitroaniline수율 46%

실험 절차

The wet mixture of 2-acetylamino-3-nitrotoluene (4) and 2-acetylamino-5-nitrotoluene as obtained in Preparation Example 1 was placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid was added thereto. Immediately on heating and boiling, the mixture was hydrolyzed. The boiling was continued until 36 l of a distillate was collected. On cooling the distillate, there was obtained 2-amino-3-nitrotoluene (5) as an orange needle-like crystal having a melting point of 92.8° to 93.2° C. in a percent yield of 46%.

후처리

  1. customas obtained in Preparation Example 1
  2. distillationwas placed in a steam distillation apparatus, and 300 ml of concentrated hydrochloric acid
  3. additionwas added
  4. temperatureImmediately on heating
  5. customwas collected
  6. temperatureOn cooling the distillate, there

출처 및 근거

ORD 기록
ord-e71ff216167e417e8e249f29fb9d1493
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05087728

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