Ammonium Hydroxide → HCID 15079241, 화합물

HRID 1534409노트

반응식

HRID 1534409 반응식
[CH2:1]([N:8]1[CH:12]=[C:11]([C:13](OCC)=[O:14])[N:10]=[C:9]1[CH2:18][OH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[NH4+:21]>C(O)C>[CH2:1]([N:8]1[CH:12]=[C:11]([C:13]([NH2:21])=[O:14])[N:10]=[C:9]1[CH2:18][OH:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 15079239HCID 15079239, 화합물

생성물 1

HCID 15079241HCID 15079241, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
50 °C

실험 절차

A mixture of ethyl 1-benzyl-2-hydroxymethylimidazole-4-carboxylate (described immediately above, 1 g), an aqueous ammonium hydroxide solution (specific gravity 0.88 g/ml, 60 ml) and ethanol (25 ml) was stirred at laboratory temperature for 48 hours and then heated to 50° C. for 4 hours. The mixture was evaporated to give 1-benzyl-2-hydroxymethylimidazole-4-carboxamide, m.p. 204°-207° C.

후처리

  1. customThe mixture was evaporated

출처 및 근거

ORD 기록
ord-743a669e161d4050b76a2c97b459e803
출처 데이터셋
uspto-grants-1992_02
특허 번호
US05089499

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