Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(Benzoyloxymethyl)phenylaminoacrylate → 4-Hydroxyquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(Benzoyloxymethyl)phenylaminoacrylate | HCID 86745485 | — |
| 용매 | Diphenyl Ether | HCID 7583 | — |
| 생성물 | 4-Hydroxyquinoline | HCID 69141 | 110.6% |
반응 단계
Diphenyl ether (500 ml) was heated to reflux, ethyl 2-isobutyryl-3-(2-(benzoyloxymethyl)phenylaminoacrylate (29.3 g, 74.1 mmol) added, and heating continued for 15 minutes. The bulk of the diphenyl ether was removed by vacuum distillation, and the residue chromatographed (silica gal, 1%-2.5% methanol in dichloromethane) and recrystallized from ethyl acetate to give 3-isobutyryl-8-benzoyloxymethyl)-4(1H)-quinolone (11.9 g, 46%), m.p. 158°-160°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05089504 |
| 출처 데이터셋 | uspto-grants-1992_02 |
| ORD ID | ord-36dd0607720a449fa5bd347b95783b9a |
| 출처 메모 | uspto-grants-1992_02 |