Methanol → Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-
반응식
C([O:4][CH:5]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]#[C:12][CH2:13][N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH2:6]1)(=O)C.C(=O)([O-])[O-].[Na+].[Na+].CO>ClCCl>[OH:4][CH:5]1[CH2:9][CH2:8][N:7]([CH2:10][C:11]#[C:12][CH2:13][N:14]([CH3:18])[C:15](=[O:17])[CH3:16])[CH2:6]1참가 물질
5
실험 절차
A mixture of 820 mg of (racemic)-N-[4-[3-(acetyloxy)-1-pyrrolidinyl]-2-butynyl]-N-methyl acetamide, 635 mg of sodium carbonate and 40 ml of methanol was stirred overnight. An equal volume of dichloromethane was added, the mixture filtered and the solvents concentrated. This residue was purified by chromatography (alumina), giving 500 mg of the desired product as a yellow oil.
후처리
- filtrationthe mixture filtered
- concentrationthe solvents concentrated
- customThis residue was purified by chromatography (alumina)
출처 및 근거
- ORD 기록
- ord-799e3313030c42a7b6bc1235ee0f4a33
- 출처 데이터셋
- uspto-grants-1992_02
- 특허 번호
- US05089518
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