HCID 19908244, 화합물 → HCID 19908238, 화합물
반응식
[BrH:1].C([CH:9]1[NH:17][CH2:16][CH2:15][C:14]2[CH2:13][NH:12][CH2:11][C:10]1=2)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[BrH:1].[BrH:1].[C:10]12[CH2:11][NH:12][CH2:13][C:14]=1[CH2:15][CH2:16][NH:17][CH2:9]2참가 물질
5
실험 절차
0.7 g of N3 -(benzyl)-3,8-diazabicyclo[4.3.0]non-1(6)-ene hydrobromide, prepared in Preparation 10, was dissolved in 20 ml of 5% aqueous acetic acid solution. 0.5 g of 10% palladium charcoal in this solution was suspended and the reaction mixture was refluxed under the hydrogen stream for 7 hours. The solid was filtered off. The filtrate was concentrated under reduced pressure and dissolved in 10 ml of 48% bromic acid. By concentrating the solution under reduced pressure again, 0.5 g of the title compound was obtained (yield 73%).
후처리
- filtrationThe solid was filtered off
- concentrationThe filtrate was concentrated under reduced pressure
- dissolutiondissolved in 10 ml of 48% bromic acid
- concentrationBy concentrating the solution under reduced pressure again
출처 및 근거
- ORD 기록
- ord-da4d73249d384909a40fd7715c1f516b
- 출처 데이터셋
- uspto-grants-1992_02
- 특허 번호
- US05089621
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