2-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester → 7-[2-(4-Methylpiperazin-1-yl)pyridin-4-yl]-1-[5-(trifluoromethyl)furan-2-ylmethyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

반응식

[CH3:22][N:23]1[CH2:24][CH2:25][N:26]([c:29]2[n:30][cH:31][cH:32][c:33]([B:35]3[O:36][C:37]([CH3:38])([CH3:39])[C:40]([CH3:41])([CH3:42])[O:43]3)[cH:34]2)[CH2:27][CH2:28]1.[I:1][c:2]1[cH:3][c:4]2[c:5]([n:20][cH:21]1)[NH:6][CH2:7][CH2:8][N:9]2[CH2:10][c:11]1[o:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]1>>[c:2]1(-[c:33]2[cH:32][cH:31][n:30][c:29]([N:26]3[CH2:25][CH2:24][N:23]([CH3:22])[CH2:28][CH2:27]3)[cH:34]2)[cH:3][c:4]2[c:5]([n:20][cH:21]1)[NH:6][CH2:7][CH2:8][N:9]2[CH2:10][c:11]1[o:12][c:13]([C:16]([F:17])([F:18])[F:19])[cH:14][cH:15]1

참가 물질

반응물 2

HCID 27695372-(4-Methylpiperazin-1-yl)pyridine-4-boronic acid, pinacol ester

HCID 578858467-Iodo-1-[5-(trifluoromethyl)furan-2-ylmethyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

생성물 1

HCID 578861027-[2-(4-Methylpiperazin-1-yl)pyridin-4-yl]-1-[5-(trifluoromethyl)furan-2-ylmethyl]-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

출처 및 근거

ORD 기록: ord-bd9d29e052924baa8170ef67841b2240
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

반응 노트

불러오는 중…