3,4-Dichlorophenyl isocyanate → 2-(2,2-Difluorocyclopropyl)ethyl 3,4-dichlorophenylcarbamate
반응식
[F:1][C:2]1([F:8])[CH2:4][CH:3]1[CH2:5][CH2:6][OH:7].[Cl:9][C:10]1[CH:11]=[C:12]([N:17]=[C:18]=[O:19])[CH:13]=[CH:14][C:15]=1[Cl:16]>O1CCCC1>[Cl:9][C:10]1[CH:11]=[C:12]([NH:17][C:18](=[O:19])[O:7][CH2:6][CH2:5][CH:3]2[CH2:4][C:2]2([F:8])[F:1])[CH:13]=[CH:14][C:15]=1[Cl:16]참가 물질
4
실험 절차
2 g (16 mmol) 2-(2,2-Difluorocyclopropyl)ethanol, dissolved in 5 ml tetrahydrofuran (THF) was treated with 3 g (16 mmol) of 3,4-dichlorophenyl isocyanate. After 6 hours reaction time at room temperature, the mixture was concentrated in vacuo and the residue recrystallised from cyclohexane. A sample was analysed by thin layer chromatography (hexane:ethyl acetate=1:1) (Rf=0.54).
후처리
- customAfter 6 hours reaction time at room temperature
- concentrationthe mixture was concentrated in vacuo
- customthe residue recrystallised from cyclohexane
출처 및 근거
- ORD 기록
- ord-dc7b3344e17a4f34a405b38352ae2656
- 출처 데이터셋
- uspto-grants-1992_02
- 특허 번호
- US05089662
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