Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 15348생성일: 2026년 10월 25일
Water → Butyl (2E)-3-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-(methyloxy)-2-pyridinyl]-2-propenoate
https://huagongshe.com/reaction/15348
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Butyl Acrylate | HCID 8846 | — |
| 반응물 | N-Methyl dicyclohexylamine | HCID 24210 | — |
| 반응물 | 4-(((tert-Butyldimethylsilyl)oxy)methyl)-2-chloro-6-methoxypyridine | HCID 57486888 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 촉매 | HCID 178418851 | HCID 178418851 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Butyl (2E)-3-[4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-(methyloxy)-2-pyridinyl]-2-propenoate | HCID 57486889 | 68% |
반응 단계
A solution of 2-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-6-(methyloxy)pyridine (9.20 g, 32.01 mmol) in 1,4-dioxane (100 ml) was treated with Pd(Pt-Bu3)2 (327 mg, 0.64 mmol), Pd2(dba)3 (293 mg, 0.32 mmol), Cy2NMe (7.53 ml, 35.21 mmol) and n-butyl acrylate (5.96 ml, 41.62 mmol). The reaction was heated at 120° C. for 1 h and was then treated with water extracted 3× with diethyl ether, dried (magnesium sulphate), evaporated and chromatographed on silica gel (250 g), eluting with 1:4 ethyl acetate-hexane to give the desired product (8.25 g, 68%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732461B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-b6a97985058d4259ad42a7b03ab67cf0 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
