Oxalyl chloride → 2-Chloro-2-oxoethyl hexanoate

반응식

[C:1]([CH2:8][C:9]([OH:11])=[O:10])(=O)[CH2:2][CH2:3][CH2:4]CC.[C:12](Cl)(=O)[C:13]([Cl:15])=[O:14]>>[C:9]([O:11][CH2:12][C:13]([Cl:15])=[O:14])(=[O:10])[CH2:8][CH2:1][CH2:2][CH2:3][CH3:4]

참가 물질

반응물 2

HCID 65578Oxalyl chloride

HCID 1288593-Oxooctanoic acid

생성물 1

HCID 147665592-Chloro-2-oxoethyl hexanoate

반응 조건

온도: 55 °C

실험 절차

8.7 gm (0.05 mole) of hexanoylacetic acid and 12.7 gm (0.10 mole) of oxalyl chloride were mixed together at room temperature. The reaction was heated gradually over one hour at 50-60° C. for about two hours. Excess oxalyl chloride was removed under reduced pressure to yield an oil that exhibits no --OH stretch by IR. Weight was 9.6 gm.

후처리

customExcess oxalyl chloride was removed under reduced pressure
customto yield an oil that

출처 및 근거

ORD 기록: ord-66c59644c1aa45b0a34ad3780e11adf1
출처 데이터셋: uspto-grants-1992_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05091560

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