4-Fluoro-3-methylbenzoyl chloride → N-{3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-4-fluoro-3-methylbenzamide

반응식

[F:30][c:31]1[c:32]([CH3:40])[cH:33][c:34]([C:35](=[O:36])[Cl:37])[cH:38][cH:39]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]([CH3:29])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14][CH3:15])[n:13]2)[n:16](-[c:21]2[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]2[F:27])[c:17](=[O:20])[cH:18][cH:19]3)[cH:7]1>>[NH:1]([c:2]1[cH:3][cH:4][c:5]([CH3:29])[c:6](-[c:8]2[c:9]3[c:10]([n:11][c:12]([S:14][CH3:15])[n:13]2)[n:16](-[c:21]2[c:22]([F:28])[cH:23][cH:24][cH:25][c:26]2[F:27])[c:17](=[O:20])[cH:18][cH:19]3)[cH:7]1)[C:35]([c:34]1[cH:33][c:32]([CH3:40])[c:31]([F:30])[cH:39][cH:38]1)=[O:36]

참가 물질

반응물 2

HCID 27745894-Fluoro-3-methylbenzoyl chloride

HCID 592126794-(5-amino-2-methylphenyl)-8-(2,6-difluorophenyl)-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one

생성물 1

HCID 11947857N-{3-[8-(2,6-difluorophenyl)-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-4-yl]-4-methylphenyl}-4-fluoro-3-methylbenzamide

출처 및 근거

ORD 기록: ord-9c6d7f5b404147908e8624c1b496095e
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

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