Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzenesulfonic Acid → Clopidogrel Besylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzenesulfonic Acid | HCID 7371 | — |
| 반응물 | Clopidogrel | HCID 60606 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Clopidogrel Besylate | HCID 9847991 | — |
반응 단계
Clopidogrel base was dissolved in methanol to obtain a clear solution. Benzenesulfonic acid was added to the solution at 20° C. The reaction mixture was heated to reflux temperature for 2 to 10 hrs. The solvent was evaporated to dryness under reduced pressure to obtain the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732608B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-6048977fc62747ef9066cb73c267c532 |
| 출처 메모 | uspto-grants-2010_06 |