참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzenesulfonic Acid | HCID 7371 | — |
| 반응물 | Clopidogrel | HCID 60606 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Clopidogrel Besylate | HCID 9847991 | — |
반응 단계
Clopidogrel base was dissolved in diethyl ether at 20-25° C. To this was added benzene sulphonic acid dissolved in diethyl ether. The reaction mixture was stirred at 25-30° C. for 24-30 hrs. The white solid was collected by filtration, washed with diethyl ether, and dried at 50-60° C. in a vacuum oven to obtain Clopidogrel besylate crystalline form.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07732608B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-af1d0da647c244b5a90bdaf4cf6fec21 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
